ISO 27001

The independent platform for sharing experiences with medication

The independent platform for sharing experiences with medication

A professional outlook on Amitriptyline

Bojan Nikolik

Bojan Nikolik

6e jaars farmaciestudent

5written expert review(s)


 depression - antidepressant tca Effectiveness: 4

Amitryptiline for depression and anxiety

Condition for which this medication is usually prescribed


Short description of this condition

Depression is a psychological disorder that is characterized by constant dejection and a loss of pleasure in life. It is often combined with worrying and a high level of concern, anxiety, sleeping disorders, fatigue, and a loss of interest and satisfaction. Different causes can be the basis of the start of depression, but it is often associated with a reduction of certain substances (neurotransmitters) like serotonin in the brain.

Effect of this medication

Amitryptiline falls in the category of tricyclic antidepressants. It is believed to work for depression and anxiety because it increases the quantity of serotonin and noradrenaline in the brain.

Advice on this condition

To reduce the likelihood of side effects, it is best to spread the medication throughout the day or to take it before going to bed. Do not just stop taking amitryptiline; if you stop taking it too quickly you may suffer from withdrawal symptoms. Take care when consuming alcohol as it may worsen the side effects.

Common side effects

Particularly when you first start taking it: drowsiness/fatigue, dry mouth, dizziness. In the long term: weight gain, constipation, palpitations.

Advice with regard to these side effects

Most side effects reduce after the first few days. Chewing gum helps to stimulate saliva production if you have a dry mouth. When you start taking it, avoid driving as your reaction times may be compromised. Dizziness most often occurs when rising from a lying position, so keep this in mind. If you are suffering from constipation, eat plenty of fibre-rich food, such as dark bread and bananas. Palpitations are often harmless, but discuss this with your doctor if you have a heart disease or arrhythmia.

Any other expert information?

Amitriptyline is also prescribed for neuropathic pain, migraines and occasionally for bedwetting.